Vitamins C and E: Beneficial effects from a mechanistic perspective
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چکیده
منابع مشابه
Vitamins C and E: beneficial effects from a mechanistic perspective.
The mechanistic properties of two dietary antioxidants that are required by humans, vitamins C and E, are discussed relative to their biological effects. Vitamin C (ascorbic acid) is an essential cofactor for α-ketoglutarate-dependent dioxygenases. Examples are prolyl hydroxylases, which play a role in the biosynthesis of collagen and in down-regulation of hypoxia-inducible factor (HIF)-1, a tr...
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Background: Oxidative modification of low-density lipoprotein (LDL) appears to be an early step in the pathogenesis of atherosclerosis. Meanwhile, myeloperoxidase (MPO)-catalyzed reaction is one of the potent pathway for LDL oxidation in vivo. The aim of this study was to evaluate in vitro antioxidant effects of vitamins C and E on LDL oxidation mediated by MPO. Methods: MPO was isolated from f...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2011
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2011.05.017