Vitamins C and E: Beneficial effects from a mechanistic perspective

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Vitamins C and E: beneficial effects from a mechanistic perspective.

The mechanistic properties of two dietary antioxidants that are required by humans, vitamins C and E, are discussed relative to their biological effects. Vitamin C (ascorbic acid) is an essential cofactor for α-ketoglutarate-dependent dioxygenases. Examples are prolyl hydroxylases, which play a role in the biosynthesis of collagen and in down-regulation of hypoxia-inducible factor (HIF)-1, a tr...

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ژورنال

عنوان ژورنال: Free Radical Biology and Medicine

سال: 2011

ISSN: 0891-5849

DOI: 10.1016/j.freeradbiomed.2011.05.017